Letter requesting Sargent's advice on the possible nomination of John M. Clayton for a cabinet position.

Letter discussing a debate Clayton had with a friend over the representation of New England states in the offices of President and Vice President. He also discusses possible candidates and retells a racy story.

Letter warning Sargent against starting a personal quarrel with a Mr. Webb. He also discusses the bartering of a tariff bill for _a slice of Oregon._

Note requesting that Sargent come to see Clayton in Washington.

Letter requesting Johnson's influence to get Sargent appointed as head of a Bureau in Washington.

Letter ridiculing Sen. Lewis Cass of Michigan for a lack of geographic knowledge. He also discusses disagreements with other senators over Central America.

Letter containing a cryptic prediction, possibly of the Civil War, that, _something extraordinary is in the wind._ Clayton also asks Sargent to arrange room and board for him in the summer.

Letter discussing his planned arrival in Washington and an anticipated trip to the Library of Congress.

Letter informing Sargent that Clayton must delay his trip to Washington due to heart problems. Clayton also discusses Virginia and Delaware politics.

Letter expressing Clayton's fear that he may have heart disease. Clayton also expresses disappointment at not being able to see Sargent.

Letter expressing Clayton's anger that opponents of Sargent engaged in a _vile trick to dispute your election._ Clayton also urges Sargent to call a meeting of the Know-Nothing Party.

Letter expressing Clayton's concern over growing sectionalism, and his belief that the Compromise of 1850 only worsened matters. Clayton also references the events known as _Bleeding Kansas_, and notes an opinion that several states may secede.