Letter discussing scientific lectures, the re-election of Pennsylvania Gov. Joseph Ritner, and Massachusetts's reluctance to support William Henry Harrison.

Letter discussing rumors of Henry Clay's plans to run for President, and Antimasonic opposition to William Henry Harrison.

Letter describing the recent debate over the reorganization of Kansas, the Fugitive Slave Law, and a vote on the unconstitutionality of the Compromise of 1850.

Letter expressing New York Governor Hamilton Fish's support of Sargent to the appointment of the 6th Auditor of Washington.

Three notes from Henry Clay regarding a valedictory speech.

Handwritten copy, by Sargent, of a letter from Henry Clay expressing his desire to see Sargent appointed to public office.

Letter discussing Clay's complaints about the Antimasonic Party, who caused problems for Whig politicians campaigning in the 1840 elections.

Letter discussing recent midterm election results and possible Whig strategies for the 1845 election.

Letter discussing another letter sent to Clay which he desires to be published. It is from a Gen. Bradley, who Clay identifies as a political enemy.

Letter expressing Clay's regret that he was not present to influence the voting on Sargent's confirmation.

Letter discussing Hitchcock's recent negotiations with the Bank of the United States.

Letter regarding the commencement of building activities, including four brick stores and a cotton prep house.