Letter requesting Sargent's advice on the possible nomination of John M. Clayton for a cabinet position.

Letter discussing a debate Clayton had with a friend over the representation of New England states in the offices of President and Vice President. He also discusses possible candidates and retells a racy story.

Letter informing Sargent that Clayton must delay his trip to Washington due to heart problems. Clayton also discusses Virginia and Delaware politics.

Letter expressing Clayton's fear that he may have heart disease. Clayton also expresses disappointment at not being able to see Sargent.

Letter expressing Clayton's dissatisfaction with a price being charged him by a boarder. He also expresses his opinion that the Know-Nothing Party must stop secret nominations if they are to survive. Written exactly one year to the day of his…

Letter discussing strategy for the 1856 election between Zachary Taylor and Lewis Cass. Attention is also given to the expected congressional gains for the Whig party.

Letter regarding an article published in the American.

Letter discussing the regional differences for the Presidential nomination, the formation of a national convention, and negotiations with the American party over the nomination.

Letter regarding the Report on African Colonization.

Letter expressing Sergeant's desire to serve Sargent.

Letter informing Sargent that it may be possible to recommend him to a committee. Sergeant also expresses his opinion that William Henry Harrison will be the best opponent for Martin Van Buren in the Presidential election.

Letter detailing Fillmore's denouncement a letter sent without his approval by Daniel Webster, and his attempt to discover how the error occurred.