Letter discussing the regional differences for the Presidential nomination, the formation of a national convention, and negotiations with the American party over the nomination.

Letter regarding an article published in the American.

Letter discussing strategy for the 1856 election between Zachary Taylor and Lewis Cass. Attention is also given to the expected congressional gains for the Whig party.

Letter expressing Clayton's dissatisfaction with a price being charged him by a boarder. He also expresses his opinion that the Know-Nothing Party must stop secret nominations if they are to survive. Written exactly one year to the day of his…

Letter expressing Clayton's fear that he may have heart disease. Clayton also expresses disappointment at not being able to see Sargent.

Letter informing Sargent that Clayton must delay his trip to Washington due to heart problems. Clayton also discusses Virginia and Delaware politics.

Letter discussing a debate Clayton had with a friend over the representation of New England states in the offices of President and Vice President. He also discusses possible candidates and retells a racy story.

Letter requesting Sargent's advice on the possible nomination of John M. Clayton for a cabinet position.

Letter expressing Clayton's anger that opponents of Sargent engaged in a _vile trick to dispute your election._ Clayton also urges Sargent to call a meeting of the Know-Nothing Party.

Letter discussing the possible passage of a bill that would liquidate certain claims.

Letter ridiculing Sen. Lewis Cass of Michigan for a lack of geographic knowledge. He also discusses disagreements with other senators over Central America.

Letter warning Sargent against starting a personal quarrel with a Mr. Webb. He also discusses the bartering of a tariff bill for _a slice of Oregon._