Note requesting that Sargent come to see Clayton in Washington.

Letter containing a cryptic prediction, possibly of the Civil War, that, _something extraordinary is in the wind._ Clayton also asks Sargent to arrange room and board for him in the summer.

Letter discussing his planned arrival in Washington and an anticipated trip to the Library of Congress.

Letter expressing Clayton's doubts that some Whigs will not vote in the upcoming election. He also discusses his choice for Vice President, and party disenchantment over Virginia and Massachusetts's plurality of national offices.

Letter expressing Clayton's concern over growing sectionalism, and his belief that the Compromise of 1850 only worsened matters. Clayton also references the events known as _Bleeding Kansas_, and notes an opinion that several states may secede.

Letter warning Sargent against starting a personal quarrel with a Mr. Webb. He also discusses the bartering of a tariff bill for _a slice of Oregon._

Letter ridiculing Sen. Lewis Cass of Michigan for a lack of geographic knowledge. He also discusses disagreements with other senators over Central America.

Letter discussing the possible passage of a bill that would liquidate certain claims.

Letter expressing Clayton's anger that opponents of Sargent engaged in a _vile trick to dispute your election._ Clayton also urges Sargent to call a meeting of the Know-Nothing Party.

Letter requesting Sargent's advice on the possible nomination of John M. Clayton for a cabinet position.

Letter discussing a debate Clayton had with a friend over the representation of New England states in the offices of President and Vice President. He also discusses possible candidates and retells a racy story.

Letter informing Sargent that Clayton must delay his trip to Washington due to heart problems. Clayton also discusses Virginia and Delaware politics.